Some of the folks were mentioning Gamma World as an artistic influence on the original game. And if you notice, it's post apocalyptic without being too unrealistic, no Wasteland super heroes with muscles popping. Varied use of colors, even if slightly washed out, everything doesn't look like it's covered in 2 inches of sand and dust. I think it's important to have a nice palette range with plenty of color. Fallout as an example of too many browns and rusty reds. The original Wasteland had plenty of green, plenty of water, a fair amount of radioactive desert browns and reds, lots of nuclear yellows, colored buildings, all of that. Street signs and billboard ads, in color, post-apocalyptic nature still trying to bloom. People in various colorful costumes and styles. Let all of that be represented, because we can, plus because it'd be more realistic. People who find their clothes from a 20th century junkyard wouldn't be stuck with leather browns and tans, they'd be wearing old basketball jerseys, ripped bluejeans, mismatched cowboy or army surplus boots, etc. Someone would have a mohawk. Let that unique style be represented as well. 80s rad-punks mixed in with nuclear rednecks from hell.
(i love her "No Nukes" shirt!)
And have varied terrain, some totally desert dry, some oasis like, some ruined modern architecture with shattered glass, bent steel, overgrown with green vines, etc. Mix it up, but make it full color. Mix up the character portraits too. The portraits from Wasteland were so varied and interesting, so we should have that here.