I know it is still early days, but what have we Discerned from the interviews etc thus far.
1 - Combat is going to be different from WL, closer to FO. More tactical, but also attempting to keep it from becoming onerous
2 - Overland is still going to be at a high level, and will zoom in when in "smaller" spaces (cities etc) or combat. This will keep the exploration and discovery of the original game.
3 - Setting up the Ranger Base. Somehow the player will be involved in this
4 - Party based - Almost certainly 4 PC + 3 NPC
5 - Turn based
6 - Bobby is alive and apparently pissed. (Other WL1 characters will also likely make an appearance)
7 - Start in old WL area, move to new region.
8 - Gear degredation (Weapons specificially)
http://wasteland.inxile-entertainment.com/forum/viewtopic.php?f=7&t=1293&p=40301#p40301
9 - Scavenging and resource management (water in particular)
http://wasteland.inxile-entertainment.com/forum/viewtopic.php?f=12&t=2099&p=40988#p40988
10 - Single player, not Multiplayer
http://wasteland.inxile-entertainment.com/forum/viewtopic.php?f=7&t=2105&p=40990#p40990
11 - Items that act on Skills - No Minigame skills
http://wasteland.inxile-entertainment.com/forum/viewtopic.php?f=12&t=1285&p=40305#p40305
12 - Device Agnostic (if possible)
http://wasteland.inxile-entertainment.com/forum/viewtopic.php?f=12&t=2067&p=41005#p41005
13 - Unlimited saves and hopes to be able to implement an ironman mode. Also Named Saves
http://wasteland.inxile-entertainment.com/forum/viewtopic.php?f=12&t=1042&start=500#p41043
14 - Unity Engine - Windows, Mac and Linux support
15 - Toaster Repair will be in the game in some form or another
What else?