Actually from what I heard in the first few minutes, he is suggesting something along the lines I had in mind.
You _start_ with an assignment to give you an initial "vector". In the case of WL2, the initial assignment to place a new Ranger base and then essentially "see what you can see".. The party gets to play "Lewis & Clark in the 21st Century". Once they have their foot in the door and are at Location A, there are several module-sized quests available that _they_ may choose to explore. Each of those adventures take them to other Locations, each of which reveal additional adventures taking them to additional Locations where they find additional adventures that......and so on. NONE of these adventures should be "Earth-shattering" of along the lines of "Save the planet!"
In the original WL, you had a string of adventures as you progressed along the path of the main quest. You went to Highpool and killed a rabid dog and saved Jackie. Then you went to the Ag Station and killed Harry the Bunny Master. Then you went to the Rail Nomads and was tasked to take a Visa card to the Head Crusher in Quartz. Optionally, you picked up an engine to take back to Highpool to fix their water pump. When you got Quartz, you needed to take out Ugly John. In doing so, you meet Ace and he leads you to a Great Danger in Vegas. On the way you stop at Needles and explore the mystery of the Blood Cult. It isn't until Vegas that you get nailed solidly to the main quest of "Save the Planet From the Robots!" And then when that one adventure is complete, the game ends.
Did that main quest have to be so monumental to make the game fun? A serious concern, yes, but "Save the World!"? No. Furthermore, aside from the Fat Freddy-Faran Brygo rivalry in Vegas, there really aren't any other side quests left to the game. Everything from that point is about gearing up with better weapons and armor before the Finale Confrontation.
So, start us out to Do Something to get us going. Thereafter, we follow of "See What We Could See" mission and pursue those quests that spark our interest. Our sense of accomplishment is provided by every adventure we complete. We do not "Save the World" this time around. But seriously, how many times do you have to save the world before even that looks like a routine chore?